| Wed., 24 | 13:00 | | Registration and poster set-up | | | | |
| 16:00 | | Welcome remarks | | Neal Silverman | | |
| 16:15 | 18:30 | Session I | VIRAL RECOGNITION, Moderator: Evelyn Kurt-Jones | | | |
| 16:15 | 16:50 | Talk I | Novel components in TLR signaling | Luke O’Neill | | |
| 16:50 | 17:15 | Talk II | TLR7 and Juvenile Diabetes | Robert Finberg | | |
| 17:15 | 17:40 | Talk III | Nucleic acid-sensing receptors in innate immunity | Tadatsugu Taniguchi | | |
| 17:40 | 18:05 | Talk IV | Antiviral innate immunity in drosophila | Jean-Luc Imler | | |
| 18:05 | 18:30 | Talk V | Innate recognition of virus infection | Caetano Reis e Sousa | | |
| 19:25 | 20:20 | session | Keynote Address | | | |
| 19:25 | 19:30 | Introduction | | Robert Finberg | | |
| 19:30 | 20:20 | Keynote Address | RNAi: From Mystery to Mechanism (and Back) | Craig Mello | | |
| 20:20 | | Welcome Reception | | | | |
| Thu., 25 | 08:30 | 10:30 | Session II | COMPARATIVE IMMUNOLOGY, Moderator: Alan Ezekowitz | | | |
| 08:30 | 08:40 | Moderator's Introduction | | Alan Ezekowitz | | |
| 08:40 | 09:15 | Talk I | Recognition of bacterial and parasite ligands by Toll-like receptors | Sankar Ghosh | | |
| 09:15 | 09:40 | Talk II | Differential roles of the inflammasome for the activation of IL-1 beta | Mihai Netea | | |
| 09:40 | 10:05 | Talk III | New transcriptional regulators of Drosophila immunity | Marc Dionne | | |
| 10:05 | 10:30 | Talk IV | Origins of vertebrate adaptive immunity | Zeev Pancer | | |
| 10:30 | 10:55 | Coffee and tea | | | | |
| 10:55 | 12:45 | Session III | STRUCTURE and FUNCTION, Moderator: Jerry Weiss | | | |
| 10:55 | 11:30 | Talk I | Role of Ubiquitin in Editing in Innate Immunity | Vishva Dixit | | |
| 11:30 | 11:55 | Talk II | Regulation of TLR4 activity in the airway | Jerry Weiss | | |
| 11:55 | 12:20 | Talk III | A 3-dimensional view of innate immune signalling by the Toll receptors | Nick Gay | | |
| 12:20 | 12:45 | Talk IV | The DNA sugar backbone as well as mTOR control TLR9 activation | Hermann Wagner | | |
| 12:45 | 14:00 | Lunch | | | | |
| 14:00 | 16:15 | Session IV | SIGNAL TRANSDUCTION, Moderator: Jules Hoffmann | | | |
| 14:00 | 14:35 | Talk I | Atg16L1, an autophagy protein, controls endotoxin-induced inflammasome activation | Shizuo Akira | | |
| 14:35 | 15:00 | Talk II | Inside and out: Microbial recognition and signalling in the Drosophila IMD pathway | Neal Silverman | | |
| 15:00 | 15:25 | Talk III | TLR-induced transcriptional response | Ruslan Medzhitov | | |
| 15:25 | 15:50 | Talk IV | Somatic cell genetics for the study of signalling in innate immunity | Felix Randow | | |
| 15:50 | 16:15 | Talk V | Role of dendritic cells in the in vivo responses to TLR ligands | Anthony DeFranco | | |
| 16:15 | 16:35 | Coffee and tea, snacks | | | | |
| 16:35 | 18:50 | Session V | INTRACELLULAR RECEPTORS, Moderator: Kenneth Rock | | | |
| 16:35 | 17:10 | Talk I | Activation of the NALP3 inflammasome | Jurg Tschopp | | |
| 17:10 | 17:35 | Talk II | How the innate immune system distinguishes between pathogenic and non-pathogenic microbes | Daniel Portnoy | | |
| 17:35 | 18:00 | Talk III | NALP3 inflammasome activation by lysosomal damage | Eicke Latz | | |
| 18:00 | 18:25 | Talk IV | Cell death, uric acid, and the sterile inflammatory response | Kenneth Rock | | |
| 18:25 | 18:50 | Talk V | Beta amyloid activates the NLRP3 inflammasome: potential cytopathic effect in Alzheimer's Disease | Douglas Golenbock | | |
| 19:00 | 21:00 | session | Poster Session including cocktails and hors d’oeuvres, Sala III | | | |
| Fri., 26 | 09:00 | 10:50 | Session VI | GRAM-NEGATIVE RECOGNITION, Moderator: Lee Wetzler | | | |
| 09:00 | 10:50 | Talk I | Interactions between Toll-like Receptor 4 (TLR4) Protease Activated Receptor 2 (PAR2) | Stefanie Vogel | | |
| 09:35 | 10:00 | Talk II | Evasion of LPS-TLR4 signaling and the evolution of a highly virulent pathogen | Egil Lien | | |
| 10:00 | 10:25 | Talk III | Molecules coordinating Toll-like receptor responses | Kensuke Miyake | | |
| 10:25 | 10:50 | Talk IV | The gut immune response of Drosophila | Bruno Lemaitre | | |
| 10:50 | 11:20 | Coffee and tea | | | | |
| 11:20 | 13:35 | Parallel Sessions | CO-RECEPTORS & REGULATORS, Moderator: Christopher Karp, Sala I | | INTRACELLULAR PATHOGENS, Moderator: Caetano Reis e Sousa, Sala II | |
| 11:20 | 11:55 | Talk I | TLR Regulation of the Metabolic Sequelae of High Fat Diets | Christopher Karp | Role of inflammasome and IL-1R in microbial and sterile inflammation | Gabriel Nunez |
| 11:55 | 12:20 | Talk II | The Role of the Phagosome in Sensing of Gram-positive Microbes | Lynda Stuart | Antiviral immunity: Intrinsic mechanisms at work | Sara Cherry |
| 12:20 | 12:45 | Talk III | DUBLIN is a novel negative regulator of RIG-Like Helicase Signaling | Ashley Mansell | Autophagic control of Listeria through intracellular innate immune recognition in Drosophila | Shoichiro Kurata |
| 12:45 | 13:10 | Talk IV | Endogenous danger signals trigger sterile inflammation via a heterotrimeric complex of CD36, TLR4, TLR6 | Kathryn Moore | Immunomodulation by the X-linked Inhibitor of Apoptosis Protein | Mary O’Riordan |
| 13:10 | | Talk V | Atherosclerosis and the Regulation of Inflammation | Sam Wright | Role of inflammasomes in antiviral immunity | Akiko Iwasaki |
| 13:35 | | Free Afternoon | | | | |
| 19:00 | | Portugese Wine Tasting and Reception | at Palacio do Marques de Pombal adjacent to Instituto Gulbenkian de Cienca (Registration required) | | Buses depart 19:00 from Hotel Cascais Miragem | |
| Sat., 27 | 08:30 | 10:15 | Parallel Sessions | SELECTED ABSTRACTS ONE, Moderator: Veit Hornung, Sala I | | SELECTED ABSTRACTS TWO, Moderator: Fabio Re, Sala II | |
| 08:30 | 08:45 | Talk I | Abstract 253: Regulation of Humoral and Cellular Gut Immunity by Lamina Propria Dendritic Cells Expressing Toll-Like Receptor 5 | Satoshi Uematsu | Abstract 89: Role of Rab11 in signaling and intracellular trafficking of Toll-like receptor 4 | Harald Husebye |
| 08:45 | 00:00 | Talk II | Abstract 51: The Drosophila membrane-associated protein PGRP-LF prevents IMD/JNK pathways triggering by blocking PGRP-LC acti... | Julien Royet | Abstract 70: Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis | Miguel Sanjuan |
| 09:00 | 09:15 | Talk III | Abstract 191: 5'-triphosphate-siRNA: turning gene silencing and RIG-I activation against melanoma | Hendrik Poeck | Abstract 201: Structural modeling of Toll-like receptors: science or fiction? | Andriy Kubarenko |
| 09:15 | 09:30 | Talk IV | Abstract 144: Sepsis-Induced Suppression Of Lung Host Defense Is Mediated By St2 | Jacobien Hoogerwerf | Abstract 217: Modulation of microRNA by Toll-like receptors | Fredric Sheedy |
| 09:30 | 09:45 | Talk V | Abstract 72: The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response | Tilmann Bürckstuemmer | Abstract 80: Stimulation of TLR3 and TLR4 induces Caspase-1 independent IL-1 Beta maturation | Rudi Beyaert |
| 09:45 | 10:00 | Talk VI | Abstract 199: Human-like responses to LPS in a mouse model | Lynn Hajjar | Abstract 39: The Role of IRF-5 in the antiviral and inflammatory response | Paula Pitha |
| 10:00 | 10:15 | Talk VII | Abstract 96: PISA (PYHIN protein stimulating ASC) triggers inflammasome activation in response to cytosolic B-DNA | Veit Hornung | Abstract 15: Inflammasome activation by Alum and Alum's adjuvant effect are mediated by NLRP3 | Fabio Re |
| 10:15 | 10:40 | Coffee and tea, snacks | | | | |
| 10:40 | 12:55 | Parallel Sessions | INFLAMMATORY DISEASE/ATHEROSCLEROSIS, Moderator: Peter Libby, Sala I | | PARASITES & FUNGI, Moderator: Miguel Soares, Sala II | |
| 10:40 | 11:15 | Talk I | An Overview of Inflammation in Atherothrombosis | Peter Libby | A central role for free heme in the pathogenesis of severe malaria | Miguel Soares |
| 11:15 | 11:40 | Talk II | Modulation of B cell Responses to Autoantigens by IFNa and BCR Engagement | Ann Marshak-Rothstein | Innate recognition of fungi | Gordon Brown |
| 11:40 | 12:05 | Talk III | TLR2 in the early stages of murine atherosclerosis | Peter Tobias | Role of TLRs, CLRs and NLRs in host defense against Candida albicans | Amy Hise |
| 12:05 | 12:30 | Talk IV | How a Pathogen Exploits TLR2-Mediated Inflammatory Pathways at Sites Distant from Infection | Caroline Genco | TLRs in Malaria | Ricardo Gazzinelli |
| 12:30 | 12:55 | Talk V | Toll-Like Receptors and Chlamydia pneumoniae-mediated acceleration of Atherosclerosis | Moshe Arditi | Regulation of anti-Plasmodium responses in the malaria vector Anopheles gambiae | Elena Levashina |
| 12:55 | 14:10 | Lunch | | | | |
| 14:10 | 16:25 | Parallel Sessions | GRAM-POSITIVES, TB, and BEYOND Moderator: Daniel Portnoy, Sala I | | DRUG DEVELOPMENT I, Moderator: Ofer Levy | |
| 14:10 | 14:45 | Talk I | Role of MyD88/IL-1R signaling in the stimulation of Th1 and Th17 responses by Complete Freunds Adjuvant | Alan Sher | High-throughtput screening strategies for the identification of novel Toll-like receptor agonists | Peter Morley |
| 14:45 | 15:10 | Talk II | Sensing of Gram-negative bacteria in Drosophila : relative roles of peptidoglycan fragment release, injury, and ... | Dominique Ferrandon | Development and in vivo assessment of small molecule TLR9 inhibitors | Sally Ishizaka |
| 15:10 | 15:35 | Talk III | TLR-independent type I interferon induction in response to an extracellular bacterium | Marie Charrel-Dennis | Bifunctional TLR7 and TLR9 Inhibitors: Development for Autoimmune Disease | Robert Coffman |
| 15:35 | 16:00 | Talk IV | Signaling pathways involved in bacteria-induced IFN-alpha-beta production | Gio Teti | Effects of a novel synthetic TLR9 agonist on repeated allergen challenge in allergic monkeys | Gerald Dubois |
| 16:00 | 16:25 | Talk V | Nod1 and Nod2 in innate and adaptive immunity | Dana Philpott | Preclinical proof of concept for TLR3 targeting in oncology | Yannis Morel |
| 16:25 | 16:50 | Coffee and tea, snacks | | | | |
| 16:50 | 19:05 | Parallel Sessions | REGULATION of SIGNALLING, Moderator: Luke O’Neill, Sala I | | DRUG DEVELOPMENT II, Moderator: Anthony Coyle | |
| 16:50 | 17:25 | Talk I | Lysosomal cleavage of TLR9 is a prerequisite for its function | Hidde Ploegh | Interferons, TLRs and Danger signals in autoimmune disease | Anthony Coyle |
| 17:25 | 17:50 | Talk II | Regulation of TLR-IL-1R signaling | Xiaoxia Li | Synthetic DNA-based antagonists of TLRs | Sudhir Agrawal |
| 17:50 | 18:15 | Talk III | Viral antagonism of TLR and RLR signaling reveals a role for DDX3 in innate immunity | Andrew Bowie | Oligonucleotide drugs as intentional and unintentional immune activators | Art Krieg |
| 18:15 | 18:40 | Talk IV | Distinctive role of MyD88-5 (SARM) in neurodegeneration and host defense | Ahiao Ding | IL-22 is produced by immune cells, including Th17 lymphocytes, and acts on non-immune cells to regulate local ... | Lynette Fouser |
| 18:40 | 19:05 | Talk V | The adenosine system differentially regulates TLR-mediated activation of monocytes in an age-specific manner | Ofer Levy | Development of Novel Small Molecule TLR8 Agonists in Oncology and Allergy | Robert Hershberg |
| 20:00 | | Banquet | at Museu de Marinha (Registration Required). | | Buses depart 20:00 from Hotel Cascais Miragem | |
